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Nottingham Combined
Histologic Grade

 

Tubule Formation
    1 - >75% of tumor has tubules
    2 - 10 to 75% of tumor has tubules
    3 - <10% of tumor has tubules

Nuclear Size
    1 - similar to normal duct epithelium
    2 - intermediate size nuclei
    3 - large vesicular nuclei with prominent nucleoli

Mitotic Count (calibrated to Olympus BX50-Sx Pth)
    1 - 0 to 8 mitoses per ten 40x fields (2.3 square mm)
    2 - 9 to 16 mitoses
    3 - >16 mitoses

Grade I    - Total score = 3 to 5
Grade II   - Total score = 6 to 7
Grade III - Total score = 8 to 9
 

 

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Last modified: 03/05/06